The treatment for recurrent melanoma depends on the stage of the original melanoma, the prior treatment received and the site of the recurrence.
Melanoma may return in the skin near the site of the original tumor. In general, these recurrences are treated with surgery similar to that recommended for a primary melanoma. This may include a sentinel lymph node biopsy. Depending on the thickness and location of the tumor, other treatments may be considered, such as isolated limb perfusion chemotherapy, systemic chemotherapy, immunotherapy, or radiation therapy.